Researchers solve 40-year-old Fourier Transform Mass Spectrometry phasing problem
(糖心视频) -- Scientists at the University of Warwick have developed a computation which simultaneously doubles the resolution, sensitivity and mass accuracy of Fourier Transform Mass Spectrometry (FTMS) at no extra cost.
Researchers in the University鈥檚 Department of Chemistry have solved the 40-year-old phasing problem which allows plotting of spectra in absorption mode.
This breakthrough can be used in all FTMS including FT-ICR, Orbitrap and FT-TOF instruments and will have applications in proteomics, petroleum analysis, metabolomics and pharmaceutical analysis among other fields.
Professor Peter O鈥機onnor, who co-developed the method, said: 鈥淲e have vastly improved the quality of data available at no extra cost.
鈥淔TMS is used extensively in the fields of pharmaceuticals, healthcare, industry, natural resources and environmental management so this breakthrough represents a real step towards improving research across the board in these areas.鈥�
The method is detailed in the study Absorption-Mode: The Next Generation of Fourier Transform Mass Spectra published in the journal Analytical Chemistry.
It is co-authored by Professor O鈥機onnor, Yulin Qi, Mark Barrow and Huilin Li from the University of Warwick.
More information: Paper online:
Provided by University of Warwick
