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Evolution Jan 24, 2024

A virus that infected animals hundreds of millions of years ago has become essential for the development of the embryo

All animals have evolved thanks to the fact that certain viruses infected primitive organisms hundreds of millions of years ago. Viral genetic material was integrated into the genome of the first multi-cellular beings and ...

Cell & Microbiology Jan 17, 2024

Stem cell study throws our understanding of gene regulation for a loop

The blueprint for human life lies within the DNA in the nucleus of each of our cells. In human cells, around six and a half feet of this genetic material must be condensed to fit inside the nucleus. DNA condensation is not ...

Cell & Microbiology Jan 16, 2024

Cancer-related mutations appear in stem cell derivatives used in regenerative medicine, shows study

Human pluripotent stem cells are cells that have two very important traits鈥攁 seemingly endless proliferative capability and the amazing ability to give rise to any cell in our body. These characteristics make these cells ...

Cell & Microbiology Jan 10, 2024

How pioneer transcription factors blaze the one trail that determines cell fate

One of the important breakthroughs that made it possible to program or reprogram cell fate more efficiently and with higher fidelity in a dish was discovering how to make use of a small set of molecular cowboys called pioneer ...

Molecular & Computational biology Dec 21, 2023

The future of canine stem cell therapy: Unprecedented, painless, and feeder-free

Dog owners may need to learn to appreciate their best friend's urine. Scientists at Osaka Metropolitan University have devised an efficient, non-invasive, and pain-free method to reprogram canine stem cells from urine samples, ...

Polymers Dec 20, 2023

Sustainable, more efficient synthesis route of hyaluronic acid polymers for biomedical applications

Hydrogels鈥攑olymer networks with high water content鈥攃an act as a tissue mimic, providing conditions for a viable culture of embedded cells, with various applications in biomedical engineering such as tissue engineering ...

Cell & Microbiology Dec 20, 2023

A mechanism-based theory of cellular and tissue plasticity

Cells and tissue are known to undergo significant irreversible deformations during processes such as tissue formation and embryo development. A research team led by Professor Yuan Lin from the Department of Mechanical Engineering ...

Cell & Microbiology Dec 19, 2023

Researchers discover crucial step in creating blood stem cells

A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, providing a valuable new insight in the effort to create patient-derived blood stem cells ...

Cell & Microbiology Dec 13, 2023

New embryo-like model simulates early human blood production

University of Pittsburgh researchers have developed a new embryo-like model derived from adult cells that replicates key features of early human development, including the generation of blood cells.

Biotechnology Dec 12, 2023

Could the 'central dogma' of biology be misleading bioengineers?

Today, medicines based on antibodies鈥攑roteins that fight infection and disease鈥攁re prescribed for everything from cancer to COVID-19 to high cholesterol. The antibody drugs are supplied by genetically-engineered cells ...

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